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The Holy Family Hospital in Nazareth was founded in 1882 and began its activity in Nazareth in a modest house in the center of the city and close to the Basilica of the Annunciation

The Fatebenefratelli order currently exists in 50 countries on five continents.

The hospital was established as a clinic in the old city of Nazareth and in 1884 a hospital ward with 4 beds was inaugurated and a monastery and a church were built.

In 1893 the hospital was closed due to lack of resources and it was reopened in 1899 with 30 inpatient beds.

With the outbreak of the First World War it was used as a hospital for the German army, and to this day the deceased German soldiers are buried nearby.

In 1918 it returned to function but with the outbreak of the Second World War the activity was stopped. The monks returned there only in 1958 and since then it was recognized by the Ministry of Health as a general public hospital.